Thakur department of pharmaceutics, krupanidhi college of pharmacy, bangalore560 034, india. Zs, malvern instruments malvern, uk was used to measure the size of lipid nanoparticles produced. Amikacin was encapsulated in liposomes comprised of dipalmitoyl phosphatidylcholine dppc and cholesterol via a proprietary. This system called solid lipid nanoparticles sln is defined as drug carrier in the submicron size range made of biocompatible and biodegradable lipids solid at room and body temperature. They consist of macromolecular materials in which the active principle drug or biologically active material is dissolved, entrapped, and or to. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The aim of the present study was to prepare solid lipid nanoparticles slns for the oral delivery. Research article biodistribution of amikacin solid lipid. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. Preparation, characterization and evaluation of ginkgo. The emulsifier used depends on administration routes and is more limited for. Aspects of sln stability and possibilities of sln stabilization by lyophilization and spray drying are discussed.
Optimisation and stability assessment of solid lipid. Solid lipid nanoparticles sln have emerged as a nextgeneration drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. This process is experimental and the keywords may be updated as the learning algorithm improves. Pdf solid lipid nanoparticles slns of amikacin were designed in this study for pulmonary delivery to reduce the dose or its administration intervals. Systems, such as solid lipid nanoparticles, polymeric nanoparticles and.
Formulation of solid lipid nanoparticles sln using. The purpose of this study was to investigate the inhalation of a liposomal formulation of amikacin in healthy male volunteers in terms of pulmonary deposition, clearance, and safety fol. Pdf stability and antimicrobial effect of amikacinloaded. The preparation of solid lipid nanoparticles slns suffers from the drawback of poor incorporation of. Preparation of the solid lipid nanoparticles slns was performed according to the emulsificationsolvent evaporation method described by vitorino et al. Sln combine advantages of the traditional systems but avoid some of their major disadvantages. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and sitespecific drug delivery. Stability and antimicrobial effect of amikacinloaded solid. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could. Research article biodistribution of amikacin solid lipid nanoparticles after pulmonary delivery j. Recent advances in solid lipid nanoparticle based drug. To evaluate the influence of the alteration of ionic strength, formulations with the.
Apr 30, 2017 formulation of solid lipid nanoparticles sln using chitosan to form oral insulin. Preparation, characterization and evaluation of ginkgo biloba. Freezedrying is a widely used process for improving the stability of slns. The pharmacokinetic studies presented that psln exhibited improved absorption efficiency and prolonged blood circulation times with a 1. Development and optimization of solid lipid nanoparticles of. Satheesh2 1 faculty of pharmacy, integral university, dasauli, kursi road lucknow 226026, u.
Polymeric and solid lipid nanoparticles for sustained. Stability and antimicrobial effect of amikacin loaded solid lipid nanoparticles article pdf available in international journal of nanomedicine 61. Solid lipid nanoparticles slns are interesting colloidal drugdelivery systems, since they have all the advantages of the lipid and polymeric nanoparticles. It is identical to an oilinwater emulsion for parenteral nutrition but the liquid lipid oil of the emulsion has been replaced by a solid lipid, i. Biodistribution of amikacin solid lipid nanoparticles after.
The aim of the present study is to prepare and characterize rizatriptan loaded solid lipid nanoparticles slns. Solid lipid nanoparticles slns for intracellular targeting. Recent advances in solid lipid nanoparticle based drug delivery systems rahul nair, k. Freezedrying of ampicillin solid lipid nanoparticles. Lipid nanoparticles characterization particle size zetasizer nano. Formulation of solid lipid nanoparticles sln using chitosan to form oral insulin. Introduction definition of solid lipid nanoparticles significance of lipid based systems types of solid lipid nanoparticles method of preparation of slns characterization of sln principle of drug release from slns advantages and disadvantages applications of slns 3.
Ultrasmall, mucuspenetrating solid lipid nanoparticles enhance the pulmonary delivery and antivirulence. Improved effect of amikacinloaded polyd,llactideco. Preparation and characterization of solid lipid nanoparticles. The main purpose of the present work was studying the biodistribution of amikacin solid lipid nanoparticles slns after pulmonary delivery to increase its concentration in the lungs for treatment. Development and characterization of lipid nanoparticles. In the present study, amikacin was successfully loaded into a new formulation of nanoparticles nps based on polyd,llactidecoglycolide 50. Methods of manufacture and structural properties of lipid nanoparticle drug delivery systems duration. This paper presents an overview about the selection of the ingredients, different ways of sln production and sln applications. Investigation of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapineloaded solid lipid nanoparticles.
Characterization of nebulized liposomal amikacin arikace. Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil feng shi, jihui zhao, ying liu, zhi wang, yongtai zhang, nianping fengschool of pharmacy, shanghai university of traditional chinese medicine, shanghai, peoples republic of chinaabstract. Polymeric and solid lipid nanoparticles for sustained release of carbendazim and tebuconazole in agricultural applications skip to main content thank you for visiting. Solid lipid nanoparticles sln liquid lipid in emulsion is replaced by high melting point lipid glycerides or waxes suitable typical medium size ranges from 50 500 nm at small sizes, crystal structures become dependent on surfactant and size polymorphism emulsion solid lipid nanoparticle surfactant layer liquid. Solid lipid nanoparticles by chatap authorstream presentation. Ramya sree 2 department of pharmaceutics 1, department of pharmaceutical chemistry 2, kles college of pharmacy, vidyanagar, hubli580031, karnataka, india. The purpose of this study was to investigate the inhalation of a liposomal formulation of amikacin in healthy male volunteers in terms of pulmonary deposition, clearance, and safety following nebulization with a commercial jet nebulizer. Dec 16, 2010 stability and antimicrobial effect of amikacin loaded solid lipid nanoparticles solmaz ghaffari1, jaleh varshosaz1, afrooz saadat2, fatemeh atyabi21department of pharmaceutics, faculty of pharmacy and isfahan pharmaceutical sciences research center, isfahan university of medical sciences, isfahan, iran. The main purpose of the present work was studying the biodistribution of amikacin solid lipid nanoparticles slns after pulmonary delivery to increase its concentration in the lungs for treatment of cystic fibrosis lung infections and also providing a new method for clinical application of amikacin. The aim of the present study was to prepare solid lipid nanoparticles slns for the oral delivery of. Solid lipid nanoparticles solid lipid high pressure homogenisation nanostructured lipid carrier retinyl palmitate these keywords were added by machine and not by the authors. Matrix type nanocapsules are vesicular system in which drug is essentially encapsulated.
Surface properties, cytotoxicity, cellular uptake, and. Advances in nanotechnologybased carrier systems for targeted. Development and optimization of solid lipid nanoparticles. Solid lipid nanoparticles slns of amikacin were designed in this study for pulmonary delivery to reduce the dose or its administration intervals leading to reduction of its toxicities especially in long term treatment. Development and optimization of solid lipid nanoparticles of amikacin by central composite design. Lecitinmodified solid lipid nanoparticles as carriers for oral administration of insulin. Solid lipid nanoparticles slns are interesting colloidal drugdelivery systems, since they have all. Solid lipid nanoparticles as a new colloidal drug carrier have many advantages such as drug delivery to specific sites and control drug release rate 23. Freezedrying of ampicillin solid lipid nanoparticles using. Rizatriptan loaded sln were prepared by modified solvent injection method and characterized for shape, surface morphology, particle size, and drug entrapment. The lipid core is stabilized by surfactants emulsifiers.
Improved transport and absorption through gastrointestinal. Mar 15, 20 the pharmacokinetic studies presented that psln exhibited improved absorption efficiency and prolonged blood circulation times with a 1. In the present study, a mannanbased pegrafted ligand was synthesized and used for the surface modification of dnaloaded cationic sln to. Lipid nanoparticles with a solid matrix, such as solid lipid nanoparticles sln, are an alternative nanoparticulate carrier system to polymeric nanoparticles, liposomes and ow emulsions 58. Solid lipid nanoparticles sln for controlled drug delivery. Development and optimization of solid lipid nanoparticles of amikacin by central composite design article pdf available in journal of liposome research 202. Solid lipid nanoparticles sln introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro and nanoparticles.
Lipid based drug delivery systems have been explored in different studies and have shown great potential in targeted drug delivery 22. Solid lipid nanoparticles slns of amikacin were designed in this study for pulmonary delivery to reduce the dose or its administration intervals. Lipidbased drug delivery systems have been explored in different studies and have shown great potential in targeted drug delivery 22. Pdf stability and antimicrobial effect of amikacin. Stability and antimicrobial effect of amikacinloaded solid lipid nanoparticles solmaz ghaffari1, jaleh varshosaz1, afrooz saadat2, fatemeh atyabi21department of pharmaceutics, faculty of pharmacy and isfahan pharmaceutical sciences research center, isfahan university of medical sciences, isfahan, iran. A solid lipid nanoparticle is typically spherical with an average diameter between 10 and nanometers. A gamma scintigraphy study to investigate lung deposition. Solid lipid nanoparticles slns of amikacin were designed, optimized, and characterized in vitro by varshosaz et al. Pdf biodistribution of amikacin solid lipid nanoparticles after. Technological developments and in vivo techniques to evaluate their interaction with the skin mariella bleve, franca pavanetto and paola perugini department of drug sciences. Pdf biodistribution of amikacin solid lipid nanoparticles. Solid lipid nanoparticles possess a solid lipid core matrix that can solubilize lipophilic molecules. Amikacin is one of the most effective antibiotics against pseudomonas aeruginosa infections, but because of its high toxicity, the use of this antibiotic has been clinically limited. Hydrogenated palm oil and lecithin incorporated with surfactant were mixed and formed by high pressure homogenization hph at elevated temperature.
Stability and antimicrobial effect of amikacinloaded. Recently, increasing attention has been focused on these sln as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Cationic solid lipid nanoparticles sln have established themselves during the past decades. A gamma scintigraphy study to investigate lung deposition and. Pdf development and optimization of solid lipid nanoparticles of.
Azarmi 7 department of pharmaceutics, faculty of pharmacy and drug delivery systems research center, isfahan university of medical sciences,p. Solid lipid nanoparticles slns are a wellstudied example of a nanoparticle delivery system that has emerged as a promising drug delivery vehicle in recent years. Dec 16, 2010 solid lipid nanoparticles slns of amikacin were designed in this study for pulmonary delivery to reduce the dose or its administration intervals leading to reduction of its toxicities especially in long term treatment. Advances in nanotechnologybased carrier systems for.
Varshosaz and others published biodistribution of amikacin solid lipid nanoparticles after pulmonary delivery find, read and cite all the research you need on researchgate. The presents study aimed to prepare and characterize solid lipid nanoparticles slns from palm oil materials. Mudavath hanumanaik 1, sandeep kumar patel 1 and k. The system consists of spherical solid lipid particles in the nanometer ranges, which are dispersed in water or in aqueous surfactant solution.
Solid lipid nanoparticles slns have been studied as a drugdelivery system for the. Varshosaz and others published biodistribution of amikacin solid lipid nanoparticles after pulmonary delivery find. Slns can be readily formulated for multiple applications including biosensing 1, cosmetics 2, and therapeutic delivery 37. Nanoparticles of amikacin were prepared from cholesterol by solvent diffusion technique and homogenization. It is identical to an oilinwater emulsion for parenteral nutrition but the liquid lipid oil of the emulsion has been replaced by. Varshosaz j, ghaffari s, mirshojaei sf, jafarian a, atyabi f, et al. Biodistribution of amikacin solid lipid nanoparticles. The objective of this research was to formulate ciprofloxacin cip in solid lipid nanoparticles slns in an attempt to develop a controlled drug delivery system. Stability and antimicrobial effect of amikacinloaded solid lipid nano. Cryoprotectants have been used to decrease sln aggregations during freezedrying. Preparation and characterization of rizatriptan loaded solid. The sln was prepared by an aqueous solvent diffusion method, subsequently modified with peg2000stearic acid peg2000sa as hydrophilic groups. To achieve this aim, 99m tc labelled amikacin was loaded in cholesterol slns and after in. Stability and antimicrobial effect of amikacinloaded solid lipid nanoparticles article pdf available in international journal of nanomedicine 61.
One major problem with sln is the lack of celltargeting ability. An ultrasonic meltemulsification method was used for preparing ciploaded slns. Aqueous sln dispersions are composed of a lipid which is solid both at body and room temperature, being stabilized by a suitable surfactant. Preparation and characterization of rizatriptan loaded. A modern formulation approach in drug delivery system s. Lipidbased nanoparticles as novel drug delivery systems for.
In this study, fractional factorial design was applied to examine which variables affect the physicochemical properties of amikacin slns. In conclusion, pegylated solid lipid nanoparticles had advantages in enhancing the bioavailability of oral administration. Solid lipid nanoparticles is an emerging field of nanotech. Aci and analyzed for lipidtodrug ld ww ratio, amikacin. Due to their solid matrix, solid lipid nanoparticles can protect the.
The main purpose of the present work was studying the biodistribution of amikacin solid lipid nanoparticles slns after pulmonary delivery to increase its. Solid lipid nanoparticles preparation and characterization. Solid lipid nanoparticles sln have attracted increasing attention during recent years. Matrix type nanocapsules are vesicular system in which drug is essentially encapsulated within the central core surronded. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. They can efficiently bind dna directly via ionic interaction and mediate gene transfection. Solid lipid nanoparticles slns have attracted increasing attention during recent years. Solid lipid nanoparticles the solid lipid nanoparticles slns are submicron colloidal carriers which are composed of physiological lipid, dispersed in water or in an aqueous surfactant solution. One of the situations in the treatment of disease is the. Apr 27, 2010 cationic solid lipid nanoparticles sln have established themselves during the past decades. The aim of the present study was to evaluate the potential of pegylated solid lipid nanoparticle psln as mucus penetrating particles mpp for oral delivery across gastrointestinal mucus. Pdf stability and antimicrobial effect of amikacinloaded solid lipid. Solid lipid nanoparticles a promising drug delivery system. Solid lipid nanoparticles slns of amikacin were designed in this study for pulmonary delivery to reduce the dose or its administration.
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